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Be careful taking other medicines which may also make you tired. Symptoms of serious allergic reaction may include: rash, itching, swelling, severe dizziness, trouble breathing. In many cases the frequency of adverse events during initiation of opioid therapy may be minimized by careful individualization of starting dosage, slow titration watson oxycodone and the avoidance of large rapid swings in plasma concentration of the opioid. Clinical trials comparing Oxycodone hydrochloride extended-release tablets with immediate-release Oxycodone and placebo, revealed similar adverse event profile between Oxycodone hydrochloride extended-release tablets and immediate-release Oxycodone. Because animal reproductive studies are not always predictive of human responses, ROXICODONE should be used during pregnancy only if potential benefit justifies the potential risk to the fetus. Oxycodone can pass into breast milk and may harm nursing baby.